The Artificial intelligence (AI) and Radiomic board coordinates Radiomics projects and Medical Imaging based studies proposed by multiple divisions and is responsible for their preliminary assessment, feasibility, management, supervision, support and development.

The Artificial intelligence (AI) and Radiomic board is currently directed by Prof. Roberto Orecchia and is composed by Prof. Massimo Bellomi (Radiology), Dr. Enrico Cassano (Breast Radiology, IEO), Dr. Francesco Ceci (Imaging Diagnostics, IEO), Dr. Marta Cremonesi (Radiation Research, IEO), Prof. Giuseppe Curigliano (New Drugs and Early Drug Development for Innovative Therapies, IEO), Dr. Aurora Gaeta (Biostatisticians, IEO), Prof. Sara Gandini (Biostatisticians, IEO), Prof. Barbara Jereczek (Radiotherapy, IEO), Prof. Davide La Torre (Artificial Intelligence and Mathematical Imaging, University of Milan),  Dr. Sofia Netti (Biostatisticians, IEO), Prof. Giuseppe Petralia (Radiology), Dr. Paola Queirolo (Medical Oncology of Melanoma and Sarcomas, IEO), Dr. Cristiano Rampinelli (Radiology, IEO). 

The Artificial intelligence (AI) and Radiomic board meets monthly to discuss together new proposals and the progress of ongoing studies. Since February 2022, the meetings, which are held online, include an open session for anyone who is interested.

Open meetings are scheduled every third Thursday of the month, excluding July and August, from 2:30 to 3 p.m.

We look forward to your participation. For more information and to participate, please write to [email protected]. 

The IEO Radiomic Team is a multidisciplinary group of physicians, physicists, engineers and statisticians. All of these are actively involved in radiomics projects, each dealing with their respective areas of expertise.

Clinical research questions are formulated and structured by the physicians, who are also responsible for image review and ground truth segmentation. Physicists and engineers support the process of image analysis and feature extraction. The statisticians in the group take care of radiomic model development and validation.

The IEO radiomic team consists of specialists working in different divisions and units, which include the Divisions of Radiotherapy, Radiology, Breast Imaging, Nuclear Medicine, as well as the Medical Physics, the Molecular and Pharmaco-Epidemiology Unit and the Radiation Research Unit.

People involved in radiomics projects meet in the Radiomic Team meetings held every two weeks on Monday, from 12:00 to 13:00 am.

If you are interested, please write to [email protected] to join our mailing list and be updated on meeting dates and topics.

The Radiomic Board and Radiomic Team of IEO are deeply involved in teaching activities at the University of Milan, with lectures at the master degree course in Biomedical Omics (https://www.unimi.it/it/corsi/corsi-di-laurea/biomedical-omics-bo and https://pubmed.ncbi.nlm.nih.gov/34585604/) and the elective course “La radiomica e le sue applicazioni” for Imaging and Radiotherapy Techniques students.

IEO also engages in outreach by organizing national and international webinars, conferences and workshops. Learn more in the "Courses and Webinars" section.

To date, the IEO's Radiomic Team has worked on projects on various oncological diseases, both independently and as part of national and international scientific collaborations. More specifically, the oncological diseases involved are:

-  Breast cancer

- Prostate cancer

- Lung cancer

-  Lymphoma

-  Head&neck

-  Colon

The “Radiomics in rEctal Cancer real wORld Data (RECORD)” project is a 3-year observational, retrospective, multicentre (8 Italian facilities) study funded by the Alliance Against Cancer (Alleanza Contro il Cancro, ACC). The purpose of the study is to build MRI-based radiomic models for predicting selected oncological outcomes in a cohort of 1000 patients with locally advanced rectal cancer. As far as IEO is concerned, the Divisions of Radiation Oncology and Radiology are responsible for providing clinical and annotated MRI imaging data.

From:

PETER PHAN: An MRI phantom for the optimisation of radiomic studies of the female pelvis. 

https://doi.org/10.1016/j.ejmp.2020.02.003

The IEO’s Radiomic Team is conducting several methodological studies related to the different stages of a typical radiomic workflow, spanning from image acquisition, reconstruction and pre-processing, to segmentation, feature extraction and statistical model development and validation.

Specific phantoms useful for application to radiomic and dosomic studies (pelvis MRI phantom for gynaecological pathology; breast MRI phantom; lung CT phantom) were developed. Repeatability and reproducibility of radiomic features calculation were investigated according to the variation of acquisition and reconstruction imaging parameters, and to the use of different settings for radiomic features calculation. Other projects studied image processing techniques to improve the robustness of quantitative image analysis (e.g.: intensity scale standardization, inhomogeneity correction, image filtering, customized image reconstruction) and radiomic data harmonization. The radiomics team dealt also with the evaluation, comparison and development of methods of auto-segmentation and detection with artificial intelligence techniques, including deep learning, and evaluated the impact of their use on radiomic models. Specifically, a model for auto-segmentation of prostate and a model for early detection of lung nodules have been developed. Finally, different statistical approaches were investigated looking at possible impact on results of statistical methodological choices such as features selection and classification methods.

Different steps of radiomics workflow in breast imaging

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